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发明公开
CN108570501A 多发性骨髓瘤分子分型及应用 有权 转让

多发性骨髓瘤分子分型及应用
摘要：
本发明公开了多发性骨髓瘤分子分型及应用。本发明提供了产品，包括获得或检测待测多发性骨髓瘤肿瘤患者中97个基因表达的物质；上述产品还包括运行多发性骨髓瘤贝叶斯分类器的设备；本发明鉴定出了一个与MCL1基因共表达的基因模块(简称为MCL1-M)，并应用它将多发性骨髓瘤分成为两个主要亚型，即MCL-M-High亚型和MCL-M-Low亚型。这两个亚型具有显著不同的预后与遗传学特征。
摘要（英）：

The invention discloses a multiple myeloma molecular subtype and application. The product provided by the invention comprises a substance for obtaining or detecting 97 gene expressions in a multiple myeloma cancer patient to be detected. The product further comprises equipment for operating a multiple myeloma Bayes classifier. In the invention, a gene module (MCL1-M for short) co-expressed with anMCL1 gene is identified, and the gene module is applied to divide multiple myeloma into two main subtypes, namely an MCL-M-High subtype and an MCL-M-Low subtype. The two subtypes have prognosis and genetics characteristics which are significantly different.

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