Embodiments of the invention disclose a non-coherent processing method and device for a multi-antenna signal. The method comprises the following steps of acquiring an initial signal, and processing the initial signal according to a first coding rule in order to obtain a primary coding signal, wherein the initial signal is an output signal after layer mapping according to the number of antenna panels; constructing a secondary precoding matrix according to the number of antenna panels; and processing the primary coding signal according to the secondary precoding matrix, and completing non-coherent precoding of the initial signal. According to the embodiments of the invention, a problem that the influence of a phase difference generated by a plurality of antenna panel transmission signals onsystem performance is large in the existing coherent transmission technology is solved. Precoding is carried out on transmitted data through each antenna panel, so that the non-coherent processing ofthe initial signals of different antenna panels is completed; and the influence of the phase difference of the transmission signals of the antenna panels on the system performance can be reduced, andthe signal transmission performance is improved.