The invention discloses an LCD TV (Liquid Crystal Display TV) whole De-Mura method. The method comprises the steps of A, performing random sampling on a new batch of LCDs and assembling the extractedLCD samples into an LCD TV prototype; B, performing mura data collection, data statistics and analysis on the to-be-checked LCD TV prototype to obtain mura data of the to-be-checked LCD TV prototype;C, performing comparative analysis on typical mura data collected in the current batch and typical mura data collected in the last batch; D, performing data collection, data analysis, comparison and objective effect checking on the prototype after being subjected to De-Mura data supplementation and correction so as to obtain compensatory data which meet requirements; and E, integrating the compensatory data which meet the requirements to a configuration data file of the to-be-checked LCD TV prototype for storage. As the LCDs in the same batch and the whole machine are subjected to the De-Muraprocessing in batches after the typical data is obtained through sampling, independent processing for each LCD is unnecessary, and both the display effect and the protection efficiency are realized.