The invention discloses a production method of copper sulfate. The production method comprises the following steps: adding an oxidizing agent into an acid etching waste solution to oxidize cuprous ions and ferrous ions in the acid etching waste solution; then regulating a pH value to reach 1.7 to 1.9 and carrying out stirring and reaction; then adding activated carbon again; performing settlementlayering and taking supernatant liquid to perform filtration to obtain an impurity-removed acid etching waste solution; adding soluble magnesium salt into an alkali etching waste solution and carryingout stirring and reaction; then performing settlement layering and taking supernatant liquid to obtain an impurity-removed alkali etching waste solution; performing mixed reaction on the impurity-removed acid etching waste solution and the impurity-removed alkali etching waste solution to obtain basic copper chloride; converting basic copper chloride ammonia into copper hydroxide; then performingfiltration on copper hydroxide, washing and purifying copper hydroxide and pulping copper hydroxide; then adding sulfuric acid to be acidified until pH is 0.5 to 1.0; then performing heat filtration,cooling crystallization, solid-liquid separation and drying treatment to obtain copper sulfate. Copper sulfate produced by the method can reach electroplating grade standard; moreover, a recovery ratio of copper in the etching waste solutions is high.