The invention relates to a portable large-thickness bookbinding puncher and belongs to the field of cultural and educational office equipment. The portable large-thickness bookbinding puncher comprises a puncher body 1 and a manual drill rod 2. The puncher body 1 is mainly composed of a nut 5, a top plate 6 and a base plate 8, wherein the puncher body 1 is of a C-shaped structure, an internal thread of the nut 5 and an external thread of a screw lever 4 are in screw-thread fit; and an unthreaded hole is drilled in the base plate 8, the unthreaded hole is in narrow-clearance fit with a drill bit 7, the unthreaded hole and the nut 5 are on the same axis, and the axis is perpendicular to the base plate 8. The manual drill rod 2 is formed by a handle 3, the screw lever 4 and the drill bit 7, wherein the screw lever 4 and the drill bit 7 are integrally coaxial. When the portable large-thickness bookbinding puncher works, the handle is rotated in the clockwise direction and the drill bit rotates and also moves downward under the action of screw-thread fit, so that multi-layers books are continuously cut and finally cut paper scraps can be extruded out from the unthreaded hole of the baseplate 8. Compared with the prior art, the portable large-thickness bookbinding puncher has the advantages of simple structure, small volume, light weight, large punching hole thickness and convenientcarrying, and is suitable for binding work anytime and anywhere.