The invention discloses a method for leaching amphoteric heavy metal in waste circuit boards through mechanical activation and alkaline oxidation. The method specifically comprises the following stepsthat (1) ball milling is carried out on the crushed waste circuit boards in an air atmosphere; (2) the ball-milled powder is added into a leaching solution for stirring and leaching, the leaching solution is an alkali solution, the leaching temperature is 60-90 DEG C, and leaching time is 1-3 hours; and (3) after leaching is finished, filtrate and filter residues are obtained through filtering, then step-by-step electrodeposition treatment is carried out on the filtrate, and pure tin, pure lead and pure zinc are obtained, wherein the leaching solution can be repeated used for leaching. According to the method for leaching the amphoteric heavy metal in the waste circuit boards through mechanical activation and alkaline oxidation, the leaching time is short, the cost is low, energy consumption is low, and the amphoteric heavy metal comprising the tin, the lead, the zinc and the like in components of the waste mobile phone circuit boards can be selectively leached, so that environmental-friendly and efficient separation between the amphoteric heavy metal and other metal is facilitated.