The invention relates to a fixing angle adjustable high-rise building environmental sanitation machine. The machine comprises a locking adjusting device, the fixing angle and the rotary angle of the locking adjusting device are adjustable, a cleaning manipulator is installed on the upper end face of the locking adjusting device, and the cleaning angle of the cleaning manipulator is adjustable, sothat the cleaning manipulator has a wide application range and can achieve functions of automatically cleaning spider webs, dust on a suspended ceiling and a ceiling and the like; the locking adjusting device comprises a lower locking circular platform, a rotary motor is installed in the middle of the lower locking circular platform through a motor seat, the output shaft of the rotary motor is fixedly connected with a locking installation platform, the lower end face of the locking installation platform is uniformly provided with four L-shaped limiting rods in the axial direction, the four L-shaped limiting rods are in sliding and cooperative connection with a circular flange, and the lower end of the circular flange is welded to the lower locking circular platform. By means of the machine, the automatically cleaning function of an indoor building can be achieved, and a new route of automated cleaning of the indoor building is provided.