The invention discloses a botanical fruit and vegetable universal insecticide and a use method thereof, and relates to the technical field of botanical insecticides The pesticide comprises the following raw materials: a plant extract, total isoflavones, hypericin, matrine, chlorogenic acid, garlicin, pentaerythritol, a modified medicinal carrier, a complex microbial inoculum, a thickening agent, adispersing agent and a wetting agent. The insecticide provided by the invention is simple to prepare and convenient to use, has the characteristics of being green, safe, non-toxic, strong in drug effect, quick in response, small in dosage and wide in insecticidal range, and has broad application prospects.