A filter element is provided with a cartridge locating system. The filter element includes a closed end cap and an open end cap with a tubular ring of filter media disposed between the end caps. The filter element includes an annular seal that can seal to round and non-round sealing surfaces and acts to block fluid flow between the open end cap and a pipe assembly in a pressure vessel assembly. Asupport bar is enclosed by the filter media and has a key. The filter element has a key receptacle to receive the key of the support bar. The user knows that the seal between the filter element and the pipe assembly is fully aligned and engaged when the key from the support bar fully enters the key receptacle of the filter element.