The invention belongs to the field of daily articles, and particularly provides a Pudilan oral spray and a preparation method thereof. The Pudilan oral spray is prepared from the following componentsof extracts of radix taraxaci, herba corydalis bungeanae and radix isatidis, extract of radix scutellariae, cetylpyridinium chloride, tranexamic acid, allantoin and proper auxiliary materials. The Pudilan oral spray has the advantages that the tranexamic acid allantoin generate the synergistic function with other active components, so as to prevent the oral ulcer, remove ozostomia and solve otheroral problems; the irritation to oral mucosa due to long-term adhesion can be avoided, and the Pudilan oral spray is especially suitable for a patient with oral ulcer to use.