The invention belongs to the technical field of fruit tree breeding, and particularly relates to an efficient pear tree rot disease resistance breeding method. The method comprises the steps of performing hybridized combination selection, hybridization pollination, hybrid seed lamination, seeding and transplanting and pear tree rot disease bacterium inoculation; weeding out disclosed plants according to the filial generation plant number in a hybridized combination; for the hybridized combination with the single plant number being 500 or above, weeding out the single plants with the diseased rate being 40 percent or higher and the disease spot length being 2cm or above; for the hybridized combination with the single plant number being smaller than 500, weeding out the single plants with the diseased rate being 70 percent or higher and the disease spot length being 2cm or above; then, selecting the fullest buds in a 10cm range at the topmost end of the resistance plant to be grafted onto the pyrus betulaefolia stocks.