The invention discloses a purification treatment method for acidic wastewater produced in lead-zinc smelting. The method comprises the following steps: (1) allowing acidic wastewater produced in lead-zinc smelting to flow into a neutralization tank, adding lime milk to adjust a pH value, carrying out sufficient stirring and standing successively so as to obtain sediments and a supernatant, and subjecting the sediments to press filtration so as to obtain filter residues and a filtrate; (2) allowing the supernatant and the filtrate obtained in the step (1) and produced water of a SRB reaction tower to enter a heavy metal sedimentation basin, and carrying out sufficient stirring and standing successively so as to obtain heavy metal sediments with zinc sulfide as a main component and a supernatant; (3) allowing a part of the supernatant obtained in the step (2) to flow back to the SRB reaction tower and adding a nutrient solution into the SRB reaction tower at the same time, and allowing produced water of the SRB reaction tower to overflow to the heavy metal sedimentation basin; and (4) discharging the rest supernatant left after backflowing in the step (3) as produced water. The purification treatment method of the invention can realize in-depth removal of heavy metals like lead, zinc, copper, arsenic and cadmium in acidic wastewater and recovery of zinc.