The invention provides a preparation method of a hydroxyapatite whisker-reinforced super-hard gypsum oral model. The preparation method comprises the following six steps: preparation of super-hard gypsum powder, preparation of a hydroxyapatite whisker suspension, mixing of whisker gypsum slurry, perfusion of the gypsum oral model, local observation of the gypsum oral model and dimension precisionadjustment of the gypsum oral model. The high-precision oral model with high compressive strength, hardness and bending strength is prepared by adding the hydroxyapatite whisker suspension into the super-hard gypsum powder, jointly mixing, mixing the slurry and perfusing, and is especially suitable for use as a working model to prepare a variety of high-precision dental restorations after dimension precision adjustment.