The invention provides a differential ion mobility spectrometry migration pole plate high-efficiency sealing assembly which is formed by cutting a sealing gasket material which is subjected to high-temperature processing and has no background signal. The periphery of one pole plate is flattened, fastening screws pass through PEEK material gaskets which fix the spacing between upper and lower poleplates, upper and lower poles with parallel placement of differential ion mobility spectrometry are fixed through the fastening of the screws, at the same time, the spacing between the upper and lowerpole plates is ensured by the PEEK material gaskets which fix the spacing between upper and lower pole plates, the parallelly placed upper pole plate and lower pole plate are sealed by sealing gaskets which are subjected to high temperature processing, since the sealing gaskets have certain degree of toughness compared to a PEEK material, the spacing between the pole plates is not affected whilethe sealing effect is achieved, and the problem of sealing between the parallel migration pole plates of the differential ion mobility spectrometry is solved. The differential ion mobility spectrometry migration pole plate high-efficiency sealing assembly is simple and practical, and the cost is low.