The invention discloses a quickly-adjustable orthopedic Kirshner wire positioning guide, comprising an operating table, a lifting unit, a diverting unit and a guiding unit. The lifting unit is vertically disposed on the operating table and comprises a lower shell, an upper shell, a first battery arranged in the lower shell, a first circuit board, a motor, a reducer, and a screw and lift nut in screwed fit; the diverting unit includes a barrel; a lower washer, a ball, an upper washer, a lock block and an electromagnetic switch are arranged in the barrel sequentially from bottom to top; the electromagnetic switch comprises a second battery, a second circuit board, a fixed core, an electromagnetic coil, a moving core and a spring; the second battery, the second circuit board and the electromagnetic coil form an electric loop; the guiding unit includes a guiding target sleeve, a sliding arm integrated to the guiding target sleeve and a guiding sleeve; the guiding sleeve is composed of a fixing seat and a wire guiding sleeve. The quickly-adjustable orthopedic Kirshner wire positioning guide is suitable for fixing wires fed in various directions so as to prevent deviating of the Kirshnerwires when they pierce the human body.