The invention discloses a power supply path setting method based on an intelligent terminal. By means of the intelligent terminal arranged in a power grid and in order to achieve the aim of comprehensively guaranteeing safe and stable operation of a system, the power system is made to be in the most economical, safe and stable operation state as long as possible by optimizing a power supply path under the condition of considering economic losses caused by the load level and reconstruction. The method includes the steps that an initial grid structure of the power grid is determined, and the grid structure of the power grid is initialized; a dispatching center judges whether the power supply path needs to be changed or not according to the load numerical value acquired by the intelligent terminal in real time; if the load numerical value is within an allowable range, the power supply path does not need to be changed, and the method is ended; otherwise, the method continues; the dispatching center obtains a power grid topology circuit set, and the power supply path is reset according to an objective function related to the economic losses.