The invention discloses a pomalyst gastric-soluble pellet and a preparing method thereof. The main medicine (pomalyst) is prepared into a gastric-soluble encapsulated pellet through a fluidized bed encapsulating process, and the encapsulated pellet is mixed with a filling agent, a disintegrating agent, a binding agent, a plasticizing agent, a lubricating agent and the like to prepare the gastric-soluble pellet through a dry method tabletting technology. The tablet can be directly swallowed and can also be rapidly disintegrated into the pellet in water to be conveniently taken by patients especially children having difficulty in swallowing. The pellet can ensure the accurate dosage and safe and convenient to take.