The invention provides a multi-channel communication method of a wireless sensor network. The method comprises the following steps: when sending data by using a method of selecting through a sending node and switching through a control channel, returning to the control channel if the sending node cannot be sent repeatedly, and replacing a data channel for next communication; when the sending nodeselects the next-hop node, replacing the data channel for the sending node if the link quality between the sending node and easy neighbor node cannot satisfy the requirement. The unnecessary channel switching can be reduced by combining with a routing mechanism of network layer without needing a complex whole network or subnet synchronization mechanism as long as the sending node coordinates the channel switching with the neighbor node; and the multi-channel communication can be realized by only slightly modifying the existing system; when the sending node/or receiving node is interfered, thepacket receiving rate can be improved, the time delay can be reduced, the energy consumption can be reduced, and the network survival time can be prolonged.