The invention discloses a preparation method of toxin-expelling and breast-enlarging fermented glutinous rice wine. The fermented glutinous rice wine consists of glutinous rice, distiller's yeast, mung beans and coix seeds, wherein the glutinous rice, which is warm in nature, is capable to warming and tonifying spleen and stomach, and the glutinous rice is capable of supplementing and nourishing vital qi and human body. The mung bean, when orally taken, has functions of clearing away heat and toxic materials, relieving summer heat and inducing diuresis, diminishing inflammation and relieving swelling, protecting liver and improving eyesight, and lowering blood pressure and cholesterol in blood. The coix seed is effective on tonifying spleen, excreting dampness, arresting diarrhea and expelling pus. The fermented glutinous rice wine contains hormone which can enrich cells of woman's breasts, and an alcohol ingredient of the fermented glutinous rice wine is also beneficial for improvingblood circulation of the breasts. With the implementation of the preparation method provided by the invention, the organic combination of the fermented wine and natural food materials is achieved, sothat the prepared fermented wine, as a wine product which is unique in characteristics and has a plurality of health-care functions, is rich in nutrition and is also good in taste. Meanwhile, the prepared fermented wine, which is low in alcoholic strength, can be eaten as a staple food, and the prepared fermented wine can also serve as a leisure drink; therefore, the prepared fermented wine is quite broad in application to people and quite excellent in market prospect.