A device for removing clogging fat in a blood vessel through a laser comprises an optical knife part and a blood vessel dredging part. The optical knife part comprises a laser device (12), a reflector(15) and a dichroic beam splitter (16); the laser device (12) emits a laser, the laser passes through the reflector (15) and enters the dichroic beam splitter (16) to be split, split laser beams enter an eye lens (11) and an objective lens (13) respectively, the laser beam after passing through the objective lens (13) is focused onto an optical knife, and the laser beam after passing through theeye lens (11) is collected by a CCD and processed by a computer to achieve image information collection. The blood vessel dredging part comprises a laser device (1), a combined optical fiber (2), a computer (7), a micromanipulator (3) and a metal net (6); the combined optical fiber (2) is formed by combining an imaging optical fiber and a fat-dissolving optical fiber, the combined optical fiber iscontrolled by the micromanipulator (3), and the metal net (6) is coated with lipase and used for removing excess fat in the blood vessel. Through the device, clogging fat in the blood vessel can be conveniently removed, and the problem of blood vessel clogging can be solved.