The invention belongs to the technical field of plantation of flue-cured tobacco, and relates to a method for improving the quality of flue-cured tobacco through crop rotation. Specifically, the invention relates to a method of crop rotation of the flue-cured tobacco and tumorous stem mustard. Through the crop rotation of the flue-cured tobacco and the tumorous stem mustard, the occurrence of diseases and pests can be eliminated fundamentally, the utilization rate of land can be improved, the cost of tobacco planting can be saved, the quality of soil can be improved, and the yield of tobacco leaves can be improved.