The invention discloses a liquid-seal stink isolating device. The device comprises a gas inlet, a gas outlet, a buffer cavity, grooves and a cavity upper cover, wherein the grooves are formed in the top of the buffer cavity, and the cavity upper cover comprises protruding structures; the device further comprises liquids used for isolating stink; the gas inlet and the gas outlet are formed in the side wall of the buffer cavity, and the position of the gas outlet is higher than the position of the gas inlet; and the liquids are arranged in the grooves, each of the sides, close to the inner sideof the buffer cavity, of the grooves is lower than the outer side wall of the buffer cavity, the height of each protruding structure is not higher than the vertical distance from the outer side wall of the buffer cavity to the bottom of each groove, and the maximum width of the cavity upper cover is not smaller than the maximum width between the outer side walls of the buffer cavity. According tothe device, the emission of the stink is greatly reduced, so that the working environment of workers is greatly improved; and the device is simple to install and convenient to maintain, and the deviceis particularly suitable for a low-cost factory.