The invention provides a data automatic encryption USB flash disk, which comprises a housing and a data storage device. The right end of the data storage device is provided with a USB reading connector. The data storage device is provided with a data locking module. The data locking module is provided with an unlock module. The unlock module is provided with an electronic unlock module. The housing is provided with an insert slot. The insert slot is located in the electronic unlock module. The insert slot is internally provided with an electronic key. The electronic key is matched with the electronic unlock module to control the unlock module. The data in the data storage device is read through the USB reading connector; the unlock module is controlled through the electronic key, the insert slot and the electronic unlock module; the USB flash disk is directly unlocked through the electronic key, and the USB flash disk is unlocked quickly, thereby improving user experience under the condition of ensuring safety; and the unlock module is subjected to remote control through a remote control module, thereby facilitating use of other people.