The invention discloses a data acquisition and switching system based on multiple sensors, including multiple sensors, multiple amplifiers, multiple couplers, a multiplexed analog switch, a sampling and holding module, an AD converter, a filter and an industrial personal computer. The sensors are respectively connected with the corresponding amplifiers. The output ends of the amplifiers are respectively connected with the corresponding couplers. A first output end of each coupler is connected with the multiplexed analog switch, and a second output end of each coupler is connected with the industrial personal computer. The switching signal control output end of the industrial personal computer is connected with the multiplexed analog switch. The output end of the multiplexed analog switch is connected with the AD converter. The output end of the AD converter is connected with the filter. The output end of the filter is connected with the industrial personal computer. After data sent bythe filter is received, the data is allocated to different sensors for transmission according to the switching condition of the multiplexed analog switch. The couplers couple out a very small part ofsignals and send the signals to the industrial personal computer, and thus, the industrial personal computer judges whether each channel of the multiplexed analog switch is opened or closed. The dataacquisition and switching system is convenient and reliable.