The invention discloses a processing method of a wedge-shaped light guide plate and angle-adjustable pressing roller sets. The processing method comprises the steps that solid materials used to process the light guide plate are melted into liquid resin; a plastic extrusion machine is used to extrude the liquid resin to the pressing roller sets, wherein each pressing roller set comprises a first roller and a second roller which are not parallel, an included angle exists between the first roller and the second roller, the liquid resin is extruded by the first roller and the second roller while passing through between the first roller and the second roller, and the wedged light guide plate is formed after cooling; and the pressing roller set used to produce the wedge-shaped light guide platecomprises the first roller and the second roller which are not parallel, and the included angle exists between the first roller and the second roller and the size of the angle can be adjusted. Throughadjustment of the angle and the distance between the rollers of the pressing roller set, the wedge-shaped light guide plates with different slope angles and different thicknesses can be produced; dies do not need to made for each specification of light guide plate; production cost is reduced; and continuous production can be implemented.