The invention belongs to the field of functional high molecular material, and more specifically relates to an enhanced hollow fiber ultrafiltration membrane, and a preparation method thereof. According to the preparation method, a high molecular hollow fiber is taken as a base membrane, wherein the surface of the high molecular hollow fiber is of a micropore structure; the surface of the base membrane is coated with a hydrophilic material with selective functions; penetrating of the hydrophilic material into the micropores of the base membrane is realized, and at the same time, a defect-free compact skin layer structure is formed on the surface of the base membrane and is taken as an active separating layer; and the thickness of the active separating layer is controlled to be 0.3 to 1m. The invention also provides a preparation method. The preparation method is simple; operation is convenient; the enhanced hollow fiber ultrafiltration membrane is high in mechanical strength and peel strength, excellent in separation performance, and low in preparation cost; and industrialized production is convenient to realize.