The invention provides a method for managing GPIO interrupt service of an embedded system. The method comprises a subscription management unit and a release processing engine unit of an abstract GPIOinterrupt event and a release processing example unit of a specific hardware GPIO interrupt event. By means of the method, all GPIO interrupt services in the embedded system are taken over in a unified mode, so that implementation of an ISR module of the GPIO has nothing to do with a specific hardware peripheral module, corresponding readability and maintainability are not lowered with increase ofperipheral modules, the ISR programming workload of a subscriber is relieved, and the method has good portability.