The invention belongs to the technical field of pharmaceutical preparations and particularly relates to an oral preparation containing tebipenem pivoxil and a preparation method thereof. The pharmaceutical preparation is prepared by the following steps: preparing a solid dispersion from an active ingredient tebipenem pivoxil; then crushing and screening the solid dispersion; and preapring the oralpreparation containing tebipenem pivoxil with proper diluent, adhesive, sweetening agent, lubricant, pigments and essence according to a conventional granulating process. The oral preparation containing tebipenem pivoxil prepared by the method covers strong bitterness of the drug effectively, so that the administrating compliance of a child patient is improved extremely; the dissolution rate andthe solubility of the drug are improved remarkably, and quick release of the drug is accelerated; the drug stability is increased, and the physical aging problem of conventional coating treatment is avoided; and the process is simple to operate, good in repeatability and suitable for industrial production.