Disclosed is a safe power connection system. The safe power connection system comprises a live line connection end, a null line connection end, a grounding line connection end, a power distribution controller, a detection circuit, a driving circuit, at least one execution electronic switch and an output end. In normal wiring, there is no potential difference between the null line connection end and the grounding line connection end, so that the output end can output a voltage as normal; and in wrong wiring, a potential difference exists between the null line connection end and the grounding line connection end, and the detection circuit generates a trigger signal to trigger the execution electronic switch to disconnect the internal live line or the internal grounding line of the safe powerconnection system so as to enable that the output end cannot realize power supply.