The invention discloses an anti-slip screw. The anti-slip screw comprises a screw rod, a screw point and a nut; the screw rod is fixedly mounted at the lower end of the nut; the screw point is fixedlymounted at the lower end of the screw rod; the screw rod, the screw point and the nut adopt the integrally-molded structure; a cross groove is formed in the upper end of the nut; a cylindrical grooveis formed in the center of the cross groove; and force return grooves are further formed in the two sides of the groove bottom of the cross groove and are formed symmetrically. According to the anti-slip screw, all that is required is to arrange bulges matched with the force return grooves on a matched screwdriver and directly rotate the screwdriver during dismounting of the screw, the bulges onthe screwdriver are buckled with the force return grooves, the screwdriver can provide the backward pull force for the screw during rotation, friction of the screw is guaranteed, the middle of the screwdriver is inserted in the cylindrical groove, the slipping phenomenon during dismounting of the screw is effectively prevented, and the screw is convenient and quick to dismount.