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发明授权
CN107698590B 一种不对称[3+2]环化反应合成手性五元碳环嘌呤核苷的方法 有权

一种不对称[3+2]环化反应合成手性五元碳环嘌呤核苷的方法
摘要：
本发明公开了一种不对称[3+2]环化反应合成手性五元碳环嘌呤核苷的方法，属于有机化学中不对称合成领域。以α‑嘌呤取代的丙烯酸酯和MBH碳酸酯为原料，以手性SITCP为催化剂，反应后得到手性五元碳环核苷类化合物，反应非对映选择性和对映选择性好，收率高达93％。
摘要（英）：

Belonging to the field of asymmetric synthesis in organic chemistry, the invention discloses a method for synthesis of chiral five-membered carbocyclic purine nucleoside by asymmetric [3+2] cyclization reaction. The method includes: taking alpha-purine substituted acrylic ester and MBH carbonic ester as the raw materials, adopting chiral SITCP as the catalyst, and carrying out reaction to obtain achiral five-membered carbocyclic nucleoside compound. The reaction has good diastereoselectivity and enantioselectivity, and the yield is up to 93%.

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