The invention discloses a method for guiding and locating skin detection equipment to a designated position based on a mobile phone camera. The method comprises the following steps: beginning to conduct testing; selecting a to-be-tested grid part by virtue of a mobile phone; turning on a front-facing camera of the mobile phone and capturing a human face; locating a relative coordinate system in accordance with such characteristic points as eyebrows, eyes, nose, mouth and the like; drawing a human face grid chart in GUI in accordance with proportional relations of the characteristic points; setting a target grid point as red; making hand-held detection equipment move close to a designated region; detecting the equipment and beginning to conduct tracking by virtue of the camera; drawing a guiding arrow in the position of a straight line between the central point of the detection equipment and a designated grid center in the GUI layer, and arranging corresponding animations; displaying asuccessful location mark in the GUI layer after the equipment is moved to the designated grid position; and starting skin detection logic. With the application of the method provided by the invention, automatic accurate location can be achieved, and it can guide a user to find out a correct test position.