The invention relates to a method for artificially breeding large-scale fry of odontobutis obscura and the like, and belongs to the technical field of aquatic organism research. Artificially breedinglarge-scale fry of odontobutis obscura is completed through spawning of small trash fish, observation, disinfection, artificial incubation and feeding. Compared with a method of breeding fry and the method for artificially breeding the large-scale fry of odontobutis obscura and the like in a pond, a high survival rate can be reached, and the culture benefit can be increased. The fry of small trashfish in the same water body is adopted as bait in the later breeding period, the cost is reduced, the operation is simple, and the breeding success rate is greatly increased.