The invention provides a device for regulating the operation condition of a centrifugal pump. According to the device, a pneumatic regulating valve is mounted on an outlet pipeline of a pump body; anair source is supplied to the pneumatic regulating valve through an air compressor; a pressure regulating valve is mounted between the air compressor and the pneumatic regulating valve, and used for regulating the pressure of the air supply to the pneumatic regulating valve; and meanwhile, a controller is adopted for controlling the opening degree of the pneumatic regulating valve according to thevalve flow characteristics of the pneumatic regulating valve, that is, the centrifugal pump can be randomly switched among the different working conditions within an ultra-short period of time. The device provided by the invention is simple in structure, convenient to mount, broad in use scope, easy to operate and high in precision; the test conditions for measuring the external characteristics,the vibration, the noise and the pressure pulsation of the centrifugal pump are provided when the centrifugal pump is quickly switched among all the working conditions; and the use value is very great.