The invention discloses a separation, concentration and elutriation process and system for sodium chloride and sodium sulfate in zero release of strong brine. The process primarily comprises a sodiumchloride separation and concentration process section, a sodium sulfate elutriation, separation and concentration process section and a reclaimed water collecting system; the process comprises the following steps: feeding the strong brine after hardness removal into a primary salt separating device, removing COD, silicon and carbon or reducing turbidity selectively after concentrating contributingwater of the primary salt separating device, then feeding the water into a secondary salt separating device, and evaporating and crystallizing the contributing water to prepare sodium chloride; feeding strong water and part of reclaimed water of the secondary salt separating device mixed in a proportion into a primary elutriation device, removing COD or reducing the turbidity selectively after mixing the strong water generated with the strong water of the primary salt separating device, then feeding the strong water mixed with the reclaimed water in a proportion into a secondary elutriation device, and re-concentrating the produced strong water to prepare sodium sulfate. The process and system disclosed by the invention have the advantages that high purity sodium chloride and high puritysodium sulfate can be prepared at the same time; the evaporating and crystallizing device is stable to operate, and low in investment and operation costs; and the process units are mature in technology, so that the process and system are wide in application prospect.