The invention discloses an optimization method of power grid transformer substation operation and maintenance operation orders. The method is applied to automatic check and analysis of the operation orders, and an entering and editing tool is provided in combination with a database management system and operation order generation and check algorithms, so that generation of the operation orders isautomated; meanwhile, same-source automatic generation of primary and secondary labels of substation equipment on the site is achieved. By means of the method, the labor intensity of operating personnel is relieved, so that generation of the operation orders is convenient, professional and standard, and the order appearance is attractive; meanwhile, same-source automatic generation of the primaryand secondary labels of the substation equipment on the site is achieved, the consistency of the site and relevant content of the operation orders is guranateed, and the reliability of operation and maintenance is improved.