The invention provides organic salt drilling fluid with enhancing inhibiting and blocking properties. The organic salt drilling fluid is prepared from the following materials in percentage based on mass content of water: 2 to 4 percent of salt tolerating clay, 0.3 to 0.5 percent of sodium carbonate, 30 to 60 percent of organic salt, 0.2 to 0.5 percent of shear force improving agent, 0. 5 to 2 percent of filtrate reducer, 1 to 4 percent of inhibiting and blocking agent, 1 to 4 percent of nano blocking agent, 0.2 to 0.5 percent of fluorocarbon alcohol, 0. 5 to 2.5 percent of polymeric alcohol, 0. 5 to 1 percent of inhibitor polyether amine, 1 to 2 percent of crystalline flake graphite, 3 to 5 percent of ultra-fine light calcium carbonate and 190 to 260 percent of barite. The drilling fluid solves the problems that conventional organic salt drilling fluid is weaker in blocking capability to mud shale microcrack, and is not ideal in surface hydration inhibiting property, has good inhibiting and blocking properties under the conditions of drilling shale and mudstone strata, and can meet the requirement of unconventional oil and gas well construction to water-based drilling fluid.