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发明公开
CN107551269A 周围神经的IgG刺激髓鞘再生 审中-实审 转让

周围神经的IgG刺激髓鞘再生
摘要：
本发明基于多克隆IgG能促进雪旺氏细胞成熟、分化和髓鞘产生的发现。提供通过施用多克隆IgG来治疗哺乳动物的非特发性、脱髓鞘性周围神经病变的方法，其中所述神经病变不是免疫介导或感染介导的。可用本发明治疗的脱髓鞘性周围神经病变的类型包括周围神经损伤和毒素诱导的周围神经病变。或者，多克隆IgG的组合物可直接施加到周围神经细胞以诱导成熟、分化成髓鞘形成状态，以及髓鞘表达或促进细胞存活。
摘要（英）：

The present invention is based on the discovery of polyclonal IgG's ability to promote Schwann cell maturation, differentiation, and myelin production. Methods for treating non-idiopathic, demyelinating peripheral neuropathies in mammals, where the neuropathy is not immune-mediated or infection-mediated, through the administration of polyclonal IgG are provided. Types of demyelinating peripheral neuropathies treatable with the present invention include peripheral nerve trauma and toxin-induced peripheral neuropathies. Alternatively, a composition of polyclonal IgGs can be applied directly to aperipheral nerve cell to induce maturation, differentiation into a myelinating state, and myelin expression or promote cell survival.

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