The invention discloses an accurate load control method taking economical efficiency and multi-time scale safety and stability into account, and belongs to the technical field of electric power systems and automation thereof. In order to solve the safety and stability problem of different time scales of a system in the fault development process, load shedding measure cost and electric safety accident liability cost are calculated, transient generalized economic loss, quasi-steady-state generalized economic loss and steady-state generalized economic loss indexes are built, and millisecond, second and minute coordinating accurate load control is realized. Electric power system scheduling operating staff can grasp safety operation rules of the system with complicated faults on different time scales, and adaptability of an existing load control method of three defense lines is improved, so that safety and stability control effectiveness and lean level of a large power grid are improved.