The invention provides a production process of a large-jacquard home-textile fabric interweaved by using double-color low-elasticity polyester filaments and coarse cotton. According to the production process, as raw materials, warp yarn uses T 75d/ 36f low-elasticity double-screen semi-extinction filaments, and weft yarn uses 83.3 tex/ OEC7S rotor spinning cotton yarn, wherein the warp density is 681 strands/ 10 cm, the weft yarn is 83.3 tex rotor spinning cotton yarn, the weft density is 189 strands/ 10 cm, and the width is 254 cm; the weaving process includes the steps of a sectional warping technology: the numbers of warping strands are 304*56+112*1 and 478*43+454*1, stripe width* stripe number is 47.19*56+17.39*1, and the displacement is 0.74; weaving; dressing; afterfinish: soft tentering shaping, pre-shrunking, calendaring, and soaking/ rolling in turns. The production process uses the method of thick weft yarn and low weft density, so that the thickness and fullness of fabrics are embodied, the flower pattern is three-dimensional, and diverse stereo aesthetic feelings are added for the fabrics.