The invention discloses a cabinet with high protection grade. The cabinet comprises a cabinet body, a front door plate, a left rear door, a right rear door and a side door plate and is characterized in that sealing strips are arranged in positions where the cabinet body is in contact with the front door plate, the left rear door, the right rear door and the side door plate; ventilated filtering screen components are arranged on the left rear door and the right rear door. A mounting upright column is arranged inside the cabinet body; a device bracket, a ground copper bar and a wiring trough are arranged on the mounting upright column. An explosion-proof lamp is arranged at the top of the cabinet body. The cabinet with high protection grade, disclosed by the invention, has the benefits that the sealing performance between the door plate and the cabinet body is ensured through the sealing strips; by utilizing the ventilated filtering screen components, the requirements for temperature and humidity inside the cabinet are met.