The invention belongs to the technical field of solid waste disposal, and particularly relates to a harmless disposal and comprehensive utilization method for high-salt chemical sludge. According to the method, negative-pressure cyclic heat storage, incineration and recycling equipment is adopted, maintenance and replacement are easy, the use cost of the equipment is low, harmless disposal of the high-salt chemical sludge can be achieved, salt in the sludge is recycled, the technical problem that the high-salt chemical sludge is fused, forms rings, is caked and the like under the high-temperature condition to cause severe destruction to an incinerator can be solved, the incineration effect is improved, and energy conservation and environmental friendliness are achieved.