The invention discloses a dust-free grinding device of azithromycin dispersible tablets. The dust-free grinding device comprises a bracket fixed on the ground; a pretreatment box is welded on one side of the top outer wall of the bracket; a powder storage box is welded on the other side of the top outer wall of the bracket; a first through hole is formed in the top outer wall of the pretreatment box; an elbow is inserted into the inner wall of the first through hole; the top outer wall of the elbow is in sleeve joint with a receiving hopper; a crushing box is fixed on the bottom inner wall of the pretreatment box by a screw; a second through hole is formed in the outer wall on one side of the crushing box. According to the device disclosed by the invention, the tablets can be crushed into particles and then ground through the crushing box and a grinding box, and the efficiency can be improved while the grinding workload is reduced; a filter net can screen impurities of the tablets so that the grinding device is not blocked by the impurities; a first push rod motor and an extrusion head can regulate the fineness degree of the powder; the whole device is a sealed structure, so that the whole device prevents dust and some substances in air from contacting with and damaging the equipment.