The invention discloses an agricultural irrigation pesticide mixing preparation device which comprises a mixing box, a water tank, a medicine box, a reel, a No. 1 rigid pull rope, a lifting screen plate, a stirring blade and a No. 2 rigid pull rope, the inner cavity of the mixing box is rotatably provided with a stirring rod through a bearing connection manner, the reel fixedly sleeves the top of the stirring rod, sliding sleeves are symmetrically fixedly connected with the lifting screen plate, the sliding sleeves slidably sleeves a guide rod, a No. 1 spring sleeves the outer ring of the upper part of the guide rod, a No. 2 spring sleeves the outer ring of the lower part of the guide rod, two rope buckles are symmetrically arranged on the upper surface of the lifting screen plate, the winding connection direction of the No. 1 rigid pull rope and the winding connection direction of the No. 2 rigid pull rope on the reel are same. The agricultural irrigation pesticide mixing preparation device has the advantages of simple structure, convenient use, good stirring effect, high efficiency, sufficient mixing of pesticide mixtures and improvement of mixing effect between a pesticide and clear water, and is suitable for popularization and use.