The invention relates to a cleaning agent for grease removal, and belongs to the technical field of industrial cleaning agents. The cleaning agent for grease removal is prepared from the following components in parts by weight: 10 to 20 parts of saponin extract, 5 to 20 parts of sodium carbonate, 10 to 20 parts of sodium phosphate, 5 to 15 parts of oleic acid, 10 to 20 parts of diethanol amine, 5 to 15 parts of sodium aliphatate, 2 to 8 parts of sucrose fatty acid ester, 5 15 parts of sodium dodecyl benzene sulfonate, 10 to 15 parts of ethyl alcohol, 5 to 15 parts of cellulose methyl ether, 2 to 5 parts of shaddock peel extract, 2 to 10 parts of polyetherimide, 3 to 6 parts of active silver nanoparticles, 5 to 8 parts of graphene oxide, 0.5 to 2 parts of defoaming agent and 50 to 80 parts of deionized water. The cleaning agent of the invention can quickly and effectively remove grease, has a strong cleaning effect on machine oil, anti-rust oil, mineral oil and animal and vegetable oil, has low foam and has a certain anti-rust function to metal.