The invention relates to a destruxins-containing pesticide compound for preventing and controlling crop pests. The active ingredients of the pesticide compound include destruxins and spinetoram, wherein the mass ratio of destruxins to spinetoram is at (1:15)-(15:1), preferably (1:5)-(5:1). The pesticide compound provided by the invention can be used for preparing any suitable dosage forms, including but not limited to missible oil, wettable powder, water dispersible granule, suspending agent, emulsion in water and micro-emulsion. The pesticide compound provided by the invention has excellent persistent effect and fast-acting property for preventing and controlling pests, is safe to crops and is worthy of popularization and application.