The invention relates to the field of petrochemical engineering, and discloses a hydroprocessing method of high-nitrogen tinpot heavy oil. The method comprises the following step of under the condition of hydrogenation reaction, sequentially contacting a heavy oil raw material with a protective agent, a demetallization agent and a denitrification agent, wherein the protective agent, the demetallization agent and the denitrification agent respectively contain catalyst carriers and active metal components loaded in the catalyst carriers; the catalyst carrier of at least one of the protective agent, the demetallization agent and the denitrification agent is a modified carrier; the modified carrier contains acid assistants distributed in the carrier layer by layer; the acidity of the modified carrier is gradually increased from the particle surface to the center. According to the hydroprocessing method of the high-nitrogen tinpot heavy oil provided by the invention, not only can relatively high metal, nitrogen and residual carbon removal effects be achieved, but also the catalyst has high stability and long operation time, so that the hydroprocessing method of the high-nitrogen tinpot heavy oil provided by the invention has a relatively good industrial application prospect.