The invention discloses a master-slave cooperative control system and method in a large card making device of IC cards. The system comprises a master, a FIFO concurrent unit, a card writing unit, a database server and an industrial Ethernet switch used for interconnection. Each of the FIFO concurrent unit and the card writing unit consists of an embedded type processor system and the FIFO concurrent unit and the card writing unit are connected with each other through FIFO. The master serves as a main control end of the system. The FIFO concurrent unit and the card writing unit serve as slaves of the system. The master sends COS data APUD commands and personalized data APDU commands to the slaves by use of the broadcasting technology and the unicasting technology. According to the invention, a problem of slow data reading and writing speed in the current card making processes can be solved, so the whole card making benefits are greatly improved.