The invention relates to an amide compound, a preparation method, and an application thereof, and particularly relates to a 2-{[(3-heterocyclo)acryloyl]phenyl}amino-2-oxoethanol carboxylate derivative and an application thereof. The invention solves the technical problem by providing an amide compound which can be used as an antioxidant and an agricultural pesticide. The compound is represented as the structural formula (I). According to the principle of bioactive group jointing, a heterocyclo compound is introduced into an amide compound, thereby developing a series of active compounds or active lead compounds that have novel structure and high activity. The invention lays excellent fundament for producing novel antioxidants and pesticides.