The present invention provides a large-scale multi-beam rapid station arrangement method. The method comprises: performing numbering of the multi-beam antenna wave beams according to mobile communication satellite, performing station arrangement in the service area of each wave beam according to requirements and features of spatial frequency reuse, and according to the frequency reuse relation, rapidly obtaining service area stations requiring improving gain and the co-frequency wave beam area stations required inhibiting gain of a target wave beam. The large-scale multi-beam rapid station arrangement method mainly aims at a mobile communication satellite load using a large-scale multi-beam antenna. According to the method, the rapid station arrangement of the large-scale multi-beam antenna can be realized to ensure that the service area and the sidelobe gain of the wave beam design result satisfy requirements, rapid optimization design is realized and design efficiency is ensured.